期刊
ANESTHESIOLOGY
卷 123, 期 2, 页码 346-356出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ALN.0000000000000731
关键词
-
资金
- Foundation for Anesthesia Education and Research (Schaumburg, Illinois)/Society for Neuroanesthesia and Critical Care (Richmond, Virginia) Mentored Research Training Grant
- National Institute of General Medical Sciences (Bethesda, Maryland) [UL1 RR024992]
- National Institute of General Medical Sciences [U25 MH071279-01]
- National Institute of Mental Health (Bethesda, Maryland) [F30 MH106253]
- National Institute of Neurological Disorders and Stroke (Bethesda, Maryland) [P30 NS-048056]
- Washington University Department of Anesthesiology (St. Louis, Missouri)
- Mallinckrodt Institute of Radiology (St. Louis, Missouri)
- McDonnell Center for Systems Neuroscience (St. Louis, Missouri)
Background: Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has been used to study the effects of anesthetic agents on correlated intrinsic neural activity. Previous studies have focused primarily on intravenous agents. The authors studied the effects of sevoflurane, an inhaled anesthetic. Methods: Resting-state BOLD fMRI was acquired from 10 subjects before sedation and from 9 subjects rendered unresponsive by 1.2% sevoflurane. The fMRI data were analyzed taking particular care to minimize the impact of artifact generated by head motion. Results: BOLD correlations were specifically weaker within the default mode network and ventral attention network during sevoflurane-induced unconsciousness, especially between anterior and posterior midline regions. Reduced functional connectivity between these same networks and the thalamus was also spatially localized to the midline frontal regions. The amplitude of BOLD signal fluctuations was substantially reduced across all brain regions. The importance of censoring epochs contaminated by head motion was demonstrated by comparative analyses. Conclusions: Sevoflurane-induced unconsciousness is associated with both globally reduced BOLD signal amplitudes and selectively reduced functional connectivity within cortical networks associated with consciousness (default mode network) and orienting to salient external stimuli (ventral attention network). Scrupulous attention to minimizing the impact of head motion artifact is critical in fMRI studies using anesthetic agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据