期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 85, 页码 12089-12092出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc07546h
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The chemical compound LY2874455 has the potential to overcome drug resistance driven by FGFR gatekeeper mutations. X-ray crystallographic studies provide the structural explanation for why this compound is effective against the FGFR gatekeeper mutations.
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