Layer-by-layer preparation of 3D covalent organic framework/silica composites for chromatographic separation of position isomers

A layer-by-layer approach was developed to prepare 3D covalent organic framework COF-300/silica composites (COF-300@SiO2) with uniform morphology as the stationary phase for high performance liquid chromatography separation of position isomers with high efficiency, selectivity and precision.