Mn-Fe layered double hydroxide nanosheets: a new photothermal nanocarrier for O2-evolving phototherapy

Iron-manganese layered double hydroxide nanosheets were developed as an effective photothermal nanocarrier for loading a photosensitizer. The catalase-like activity enables the nanosheets to decompose H2O2 into O-2, overcoming tumor hypoxia and enhancing O-2-dependent photodynamic therapy (PDT). The combination of PDT and photothermal therapy (PTT) can almost completely eliminate tumor tissues.