4.7 Article

Towards rational design of RAD51-targeting prodrugs: platinum(IV)-artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells

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CHEMICAL COMMUNICATIONS
卷 54, 期 83, 页码 11717-11720

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06576d

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Two Pt-IV-artesunate anticancer prodrugs that target RAD51, a crucial protein in homologous recombination mediating the sensitivity of cancer cells to DNA-damaging agents, were designed; their cytotoxicities against BRCA-proficient ovarian and breast cancer cells are significantly higher than those of cisplatin.

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