期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 78, 页码 11017-11020出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06748a
关键词
-
资金
- National Natural Science Foundation of China [21302134]
Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a BrOnsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.
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