Pro-guest and acyclic cucurbit[n]uril conjugated polymers for the controlled release of anti-tumor drugs

We report pro-guest and acyclic cucurbit[n]uril conjugated polymers as supramolecular drug delivery systems (DDSs). These supramolecular DDSs could encapsulate anti-tumor drugs. Under acidic conditions, an acid-labile pro-guest degraded to become a competing guest, which displaced and released the encapsulated drug at a tunable rate.