Oxidation-responsive Eu2+/3+- liposomal contrast agent for dual-mode magnetic resonance imaging

An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu2+ and liposomes. Positive contrast enhancement was observed with Eu2+, and chemical exchange saturation transfer was observed before and after oxidation of Eu2+. Orthogonal detection modes render the concentration of Eu inconsequential to molecular information provided through imaging.