期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 72, 页码 10513-10516出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03953j
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资金
- Advanced Production Technology Development Program
- Ministry of Agriculture, Food and Rural Affairs
- National Research Foundation of Korea (NRF) - Korean government (MEST) [2012R1A2A2A01011056]
We describe a simple, high-speed, high-throughput aptamer screening for a group of small molecules using graphene oxide (simple Multi-GO-SELEX) without immobilizing targets. The affinities of ten different ssDNA aptamers successfully obtained for three pesticides were in the range of 10-100 nM. Besides a specific aptamer for each target, we found a couple of flexible multi-target aptamers, which can bind with 2 or 3 different molecules. These flexible aptamers developed for binding with a mixture of targets are not only significant for the rapid screening of a group of small molecules but also offer great promise for aptamer-based biosensor applications.
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