期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 24, 页码 3151-3154出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00394b
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资金
- National Institutes of Health [GM106260]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1337975] Funding Source: National Science Foundation
The first catalytic asymmetric addition of ynamides to aliphatic and aromatic aldehydes is described. This reaction provides unprecedented access to a diverse family of N-substituted propargylic alcohols that are obtained in high yield and ee in the presence of 10 mol% of zinc triflate and N-methylephedrine. The use of apolar solvent mixtures is essential to avoid product racemization and to optimize ee's without compromising conversion.
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