期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 16, 页码 1986-1988出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48833k
关键词
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资金
- National Basic Research Program (973 Program) of China [2010CB833200]
- NSF of China [21332007, 21072160]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) of Ministry of Education, China
The total synthesis of the alkaloid (-)-chaetominine (1) has been achieved in four steps with an overall yield of 33.4%. Key features of our strategy include a one-pot cascade indole epoxidation - epoxide ring-opening cyclization - lactamization reaction sequence, and the use of a nitro group as a latent amino group for the one-pot construction of the quinazolinone ring. This constitutes a step economical, redox economical and protecting group-free total synthesis.
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