期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 63, 页码 8779-8782出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02570a
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资金
- Natural Science Foundation of China [51072053, 51372084, 51132009]
- Shanghai Municipal Education Commission [13zz040]
- Nano-Special Foundation for Shanghai Committee of Science and Technology [12nm0502600]
Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr-O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.
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