期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 22, 页码 2943-2946出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00181h
关键词
-
资金
- NSERC
2-Methacryloxyethyl phosphorylcholine (MPC) materials are well studied due to their excellent biocompatibility and are currently being used in many clinical applications. In this study, MPC based homopolymers and copolymers are prepared and are subsequently evaluated for their charge inversion properties in the presence of cations and subsequent DNA binding efficacies. These polymers are then studied for their epidermal growth factor receptor (EGFR) specific siRNA delivery in HeLa cells. The homopolymers of MPC and their copolymers show efficient EGFR knockdown efficacies in HeLa cells both in the presence and absence of serum proteins.
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