期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 40, 页码 5313-5315出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47444e
关键词
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资金
- Hong Kong Baptist University [FRG2/1213/ 021]
- Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
- Health and Medical Research Fund [HMRF/13121482]
- Research Grants Council [HKBU/201811, HKBU/204612, HKBU/201913]
- French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
- Science and Technology Development Fund, Macao SAR [103/2012/A3, 001/2012/A]
- University of Macau [MYRG091(Y2-L2)-ICMS12-LCH, MYRG121(Y2-L2)-ICMS12-LCH)]
A label-free, oligonucleotide-based, switch-on luminescence detection method for T4 polynucleotide kinase activity has been developed using a novel G-quadruplex-selective luminescent Ir(III) complex probe. The application of the assay for screening potential T4 PNK inhibitors is also demonstrated. To our knowledge, this is the first metal-based assay for PNK activity.
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