4.7 Article

Multivalent comb-type aptamer-siRNA conjugates for efficient and selective intracellular delivery

期刊

CHEMICAL COMMUNICATIONS
卷 50, 期 51, 页码 6765-6767

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01620c

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资金

  1. Global Innovative Research Center (GiRC) program [NRF-2012K1A1A2A01056094]
  2. Fusion Technology Project [2012K-001397]
  3. Basic Science Research Program through the National Research Foundation (NRF) - Ministry of Education, Science and Technology, Republic of Korea [NRF-2011-0023201]

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In this study, a simple and efficient strategy for selective intracellular delivery of RNA therapeutics into target cancer cells was designed using direct complementary base pairing between chemically conjugated multimeric antisense strands and aptamer-incorporating sense strands.

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