Synthesis of alkylidene pyrrolo[3,4-b]pyridin-7-one derivatives via RhIII-catalyzed cascade oxidative alkenylation/annulation of picolinamides

A practical Rh-III-catalyzed cascade olefination/annulation of picolinamides leading to pyrrolo[3,4- b]pyridines has been developed. The reaction shows wide scope, complete regiocontrol and excellent stereoselectivity.