期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 70, 页码 10027-10030出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01929f
关键词
-
资金
- National Natural Science Foundation of China [J1103304, 21103023, 21342009]
An organocatalytic cascade reaction was established for the construction of indoloquinolizidine derivatives bearing five contiguous stereo-centers from readily available aliphatic aldehydes, nitroethylenes, and tryptamine. This one-pot process gave 30-55% overall yields with excellent d.r. (> 20:1 in all cases) and ee (91-98%). Additionally, quaternary stereogenic carbon center-containing indoloquinolizidines were prepared through NBS-mediated cyclization of one of the intermediates.
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