期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 74, 页码 10797-10800出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03863k
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资金
- European Research Council under the European Community's Seventh Framework Programme (FP7)/ERC Grant [203413]
- Minerva Center for Bio-hybrid complex systems
Intrinsically disordered proteins (IDPs) or regions (IDRs) in proteins hold many functions but their biological roles are still not fully understood. Here we describe a new role of such regions. Using the HIV-1 Rev protein, we show that disordered domains have a role in maintaining the correct oligomeric state and the thermodynamic stability of proteins.
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