期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 86, 页码 13131-13134出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06016d
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资金
- CREST, Japan Science and Technology Agency
- Japan Society for the Promotion of Science
The HGF/c-Met pathway is known to play a key role in cancer metastasis. CLN0003_SL1, a 50-mer DNA aptamer that binds to the c-Met protein, was found to inhibit HGF-induced c-Met activation. This aptamer could suppress cancer cell motility in vitro.
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