期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 86, 页码 13023-13025出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06516f
关键词
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资金
- National Science Foundation
- Division Of Human Resource Development
- Direct For Education and Human Resources [1311318] Funding Source: National Science Foundation
The pacidamycin and muraymycin uridyl peptide antibiotics show some structural resemblance to an Arg-Trp-x-x-Trp sequence motif for protein-protein interaction between bacteriophage phi X174 protein E and E. coli translocase MraY. Members of the UPA class, and a synthetic uridine-peptide analogue, were found to show reduced levels of inhibition to F288L or E287A mutant MraY enzymes, implying that the UPAs interact at this extracellular site as part of the enzyme inhibition mechanism.
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