期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 93, 页码 14498-14500出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04280h
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资金
- Danish Council for Independent Research, Technology and Production Sciences, Denmark
The release of azidothymidine from macromolecular prodrugs was designed to respond to the intracellular disulfide reshuffling. This drug has no thiol groups, and a response to this trigger was engineered using a self-immolative linker. The resulting formulations were fast-acting, efficacious, and highly potent with regards to suppressing the infectivity of the virus.
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