期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 85, 页码 12832-12835出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03454f
关键词
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资金
- Office of Science (BER), U.S. Department of Energy [DE-SC0008397]
- National Cancer Institute (NCI) [R01 CA128908-03]
- NCI In Vivo Cellular Molecular Imaging Center (ICMIC) [P50 CA114747]
- China National Key Research and Development Program 973 Project [9732006CB933205]
- Science and Technology Pillar Program of Jiangsu province [BE2010721]
An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.
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