期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 89, 页码 13729-13731出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc05657d
关键词
-
资金
- Health Research Council of New Zealand [11/323]
The (OH)-O-center dot radical is released from 3-trifluoromethyl-quinoxaline 1,4-dioxides upon one-electron reduction by cytochrome P450 oxidoreductase. This process effectively competes with back oxidation of the intermediate radical anion by oxygen and underlies the increased aerobic cytotoxicity of such compounds compared to that seen for the related clinical bioreductive benzotriazine drug, tirapazamine.
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