期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 80, 页码 11806-11809出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03453h
关键词
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资金
- China Scholarship Council (CSC)
- University of Bath
- Royal Society
- MRC
- STFC
- Oriental Scholarship
- Fundamental Research Funds for the Central Universities [WK1013002]
- Science and Technology Facilities Council [ST/K002082/1] Funding Source: researchfish
- STFC [ST/K002082/1] Funding Source: UKRI
Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu2+ selective fluorescent sensor in living cells. This derivative is one of the rare examples of reversible fluorescent chemosensors for Cu2+ which uses a boronic acid group for a binding site. Moreover, the adduct BNP-Cu2+ displays a fluorescence enhancement with fructose. The uptake of this novel compound in HeLa cancer cells was imaged using confocal fluorescence microscopy techniques including two-photon fluorescence lifetime imaging microscopy.
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