期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 23, 页码 3018-3020出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47862a
关键词
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资金
- NIH [1K08CA155035-01A1]
- Dermatology Foundation
- American Skin Association
- American Cancer Association
- Max Kade Foundation
- Spanish Ministry of Economy and competitiveness [SAF2010-15440]
- IMDEA Nanociencia
- Vereinfur Dermatologie Krankenanstalt Rudolfstiftung
- Family Honzak, Vienna
Gold nanoparticles functionalized with oligonucleotides that bear a cholesterol group are used as gene sensors. The hydrophobic molecule is buried inside the nanostructure but when the complementary RNA sequence is present the structure unfolds exposing the cholesterol group to the water molecules. This rearrangement leads to the aggregation of the nanostructures.
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