4.7 Article

A light-up and spectrum-shift response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

期刊

CHEMICAL COMMUNICATIONS
卷 50, 期 54, 页码 7107-7110

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00160e

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资金

  1. National Natural Science Foundation of China [21305120, 21121091]
  2. Natural Science Foundation of Jiangsu Province, China [BK20130211]
  3. Natural Science Fund for Colleges and Universities in Jiangsu Province [13KJB150036]
  4. State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS1203]
  5. National Basic Research Program of China [2011CB933502]

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We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a light-up and spectrum-shift response to target DNA in vitro and could further image the tumor-related mRNA in living cells.

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