期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 89, 页码 13757-13760出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06340f
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资金
- National Institutes of Health NIDCR [2R01DE015920-09]
- NIBIB [5R01EB003806-09]
- Samsung Scholarship Foundation Graduate Fellowship
Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.
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