期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 51, 页码 6801-6804出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00447g
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资金
- ENIAC [CAJAL4EU]
- Momentum program of the Hungarian Academy of Sciences and of New Szechenyi Plan [TAMOP-4.2.1./B-09/1/KMR-2010-0001]
We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum.
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