期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 100, 页码 15860-15863出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06236a
关键词
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资金
- Bill and Melinda Gates Foundation
- NIH
- University of Colorado
Antimicrobial drug discovery has slowed considerably over the last few decades. One major cause for concern is the lack of innovative approaches to treat infections caused by mycobacteria such as TB. Herein we demonstrate that our Small Molecule Variable Ligand Display (SMLVD) method for nanoparticle antibiotic discovery can be expanded around a ligand feed ratio parameter space to identify gold nanoparticle conjugates that are potent inhibitors of mycobacteria growth, with our most potent inhibitor able to reduce growth by five orders of magnitude at 8 mu M.
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