4.7 Article

Synthesis of rhodamine-labelled dieckol: its unique intracellular localization and potent anti-inflammatory activity

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CHEMICAL COMMUNICATIONS
卷 50, 期 86, 页码 13045-13048

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04270k

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资金

  1. CRI project [2009-0081566]
  2. Grant of High Value-added Food Technology Development Program of Korean Ministry for Food, Agriculture and Forestry [112078-3]
  3. project Development of Concentration and Cognitive Function Improving Agent Utilizing Brown Seaweeds'' - Ministry of Oceans and Fisheries, Korea

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Rhodamine-labelled dieckol (1) synthesized through a click reaction was found to be localized in the endoplasmic reticulum (ER) of RAW 264.7 cells. Anti-inflammatory activity of compound 1 was considerably greater than that of dieckol itself.

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