期刊
CHEMICAL COMMUNICATIONS
卷 50, 期 16, 页码 2043-2045出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/C3CC48871C
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资金
- Region Haute Normandie (the CRUNCh program-CPER
- CNRS
- Labex SynOrg
The irreversible Michael addition of thiols to acrylamides is reported as a new tool for the kinetic target-guided synthesis. In an unprecedented enzymatic hydrolysis/thio-Michael addition procedure, potent and selective acetylcholinesterase inhibitors are assembled by the enzyme using both its esterasic and templating ability.
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