A bioreducible linear poly(β-amino ester) for siRNA delivery

Described here is the synthesis and characterization of a novel, bioreducible linear poly(beta-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.