Enantioselective cooperative triple catalysis: unique roles of Au(I)/amine/chiral Bronsted acid catalysts in the addition/cycloisomerization/transfer hydrogenation cascade

An enantioselective cooperative process involving the concerted/simultaneous action of three different catalysts i.e. Au(I)/amine/chiral Bronsted acid catalysts has been realized for the synthesis of 2-substituted tetrahydroquinolines from 2-aminobenzaldehydes and terminal alkynes.