期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 24, 页码 2421-2423出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc38589b
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资金
- Tianjin Municipal Applied Basic Research and Cutting-Edge Technology Research Scheme of China [11JCYBJC14400]
- Tianjin Key Science and Technology Projects of Tianjin Municipal Science and Technology Commission [12ZCDZSY11500]
Glucose-conjugated malonato-platinum(II) complexes are designed and synthesized to target tumor-specific active transporters, namely, glucose transporters (GLUTs); the complexes exhibit much higher aqueous solubility by 150 times, improved potency in cytotoxicities by 10 times, and increased therapeutic index by over 30 fold compared to the newest generation of clinical drugs oxaliplatin.
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