期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 76, 页码 8453-8455出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc44737e
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资金
- Cancer Research UK [11961, 12488] Funding Source: Medline
The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
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