4.7 Article

Highly sensitive detection of telomerase based on a DNAzyme strategy

期刊

CHEMICAL COMMUNICATIONS
卷 49, 期 26, 页码 2652-2654

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc38818b

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资金

  1. National Basic Research Program of China (973 Program) [2012CB720600, 2012CB720603, 2012 CB720605]
  2. National Science Foundation of China [91213302, 21072115]
  3. National Grand Program on Key Infectious Disease [2012ZX10003002-014]
  4. Open funding of the State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, the Chinese Academy of Sciences
  5. Program for Changjiang Scholars and Innovative Research Team in University [IRT1030]

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The present study demonstrated a highly sensitive strategy for measuring telomerase activity in cell extracts. Furthermore, we applied the new strategy for in situ detection of telomerase at the cellular level in cancer cells, together with a normal cell as the negative control.

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