4.7 Article

[18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA

期刊

CHEMICAL COMMUNICATIONS
卷 49, 期 14, 页码 1386-1388

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc38646a

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资金

  1. BBSRC
  2. GE Healthcare
  3. Academy of Finland
  4. Finnish Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research
  5. Lundbeck Foundation
  6. Carlsberg Foundation

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The Ag-mediated electrophilic [F-18]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [F-18]selectfluor bis(triflate) in acetone. The process gave 6-[F-18]-fluoro-L-DOPA with a RCY of 19 +/- 12% and a specific activity of 2.6 +/- 0.3 GBq mu mol(-1).

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