A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex

A new G-quadruplex (GQ) stabilizer, [Pt(Dip)(2)](PF6)(2) (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.