4.7 Article

Batch to flow deoxygenation using visible light photoredox catalysis

期刊

CHEMICAL COMMUNICATIONS
卷 49, 期 39, 页码 4352-4354

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc37206a

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资金

  1. NSF [CHE-1056568, CHE-0619339, CHE-0443618]
  2. Alfred P. Sloan Foundation
  3. Amgen
  4. Boehringer Ingelheim
  5. Boston University
  6. AstraZeneca
  7. American Chemical Society Division of Organic Chemistry
  8. DAAD RISE Worldwide program
  9. Direct For Mathematical & Physical Scien
  10. Division Of Chemistry [1056568] Funding Source: National Science Foundation

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Herein we report a one-pot deoxygenation protocol for primary and secondary alcohols developed via the combination of the Garegg-Samuelsson reaction, visible light-photoredox catalysis, and flow chemistry. This procedure is characterized by mild reaction conditions, easy-to-handle reactants and reagents, excellent functional group tolerance, and good yields.

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