期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 60, 页码 6746-6748出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41701h
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资金
- European Commission [MCIAPP-2009-251307, MCITN-2011-289554]
A solid-phase synthesis approach to prepare molecularly imprinted polymer nanoparticles (MIP-NPs) specific for trypsin is described. The protein is immobilized on a solid support upon which thermo-responsive MIP-NPs are synthesized. The MIP-NPs are released by a simple temperature change, resulting in synthetic antibody mimics exhibiting high specificity and selectivity for trypsin.
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