γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery

The stability and compatibility of designed coiled coil peptides towards the selective incorporation of gamma(4)-amino acids at the hydrophobic positions of the heptad repeat are studied. Investigations reveal that the low thermal denaturation temperature of gamma(4)-residue mutated coiled coils can be utilized as a mild hyperthermia trigger in liposomes.