期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 71, 页码 7815-7817出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc44039g
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资金
- NCCR Nanoscale Science
- European Science Foundation's Precision Polymer Materials (P2M) Research Networking Programme
A water-soluble squaric acid dialkyl diester derivative is presented, which enables one-pot, two-step amine-selective protein conjugation reactions with (functional) amines in water. This reagent not only allows all-aqueous protein modifications, but also tolerates e. g. hydroxyl groups and can also be used for the modification of proteins with water-insoluble amines.
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