4.7 Article

Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

期刊

CHEMICAL COMMUNICATIONS
卷 49, 期 71, 页码 7809-7811

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc44434a

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资金

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan
  2. Funding Program for Next Generation World-Leading Researchers [GR025]
  3. Grants-in-Aid for Scientific Research [24105505] Funding Source: KAKEN

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Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a high selectivity.

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