4.7 Article

Palladium-catalysed aerobic oxidative Heck-type alkenylation of Csp3-H for pyrrole synthesis

期刊

CHEMICAL COMMUNICATIONS
卷 49, 期 52, 页码 5853-5855

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42307g

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资金

  1. 973 Program [2012CB725302]
  2. National Natural Science Foundation of China [21025206, 21272180]
  3. China Postdoctoral Science Foundation [2012M521458]
  4. Program for Changjiang Scholars and Innovative Research Team in University [IRT1030]

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The first palladium-catalysed aerobic oxidative intramolecular alkenylation of Csp(3)-H bonds was described. The reaction conditions were mild and molecular oxygen was used as the terminal oxidant. Kinetic studies showed that the Csp(3)-H metallation step was a slow step.

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