期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 39, 页码 4415-4417出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36540e
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资金
- National Institutes of Health (NIH) [DA027977, DA026950, NS067425, DA025740]
Peptide nucleic acid (PNA) inhibitors of miR-221-3p (CU-PNA-221) and miR-466l-3p (CU-PNA-466) demonstrated changes in inflammatory responses. Suppression of inflammatory signalling was unexpected and further investigation led to the identification of calmodulin as a novel target of miRNA-466l-3p. These studies demonstrate that exogenous agents may suppress neuroinflammation mediated by microglial cells.
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