期刊
CHEMICAL COMMUNICATIONS
卷 49, 期 50, 页码 5630-5632出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41129j
关键词
-
资金
- Hong Kong Baptist University [FRG2/11-12/009]
- Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
- Health and Medical Research Fund [HMRF/11101212]
- Research Grants Council [HKBU/201811, HKBU/204612]
- French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
- Science and Technology Development Fund, Macao SAR [001/2012/A]
- University of Macau [MYRG091(Y2-L2)-ICMS12-LCH, MYRG121(Y2-L2)-ICMS12-LCH]
We report herein a simple and convenient luminescent assay for detection of base excision repair enzyme activity using an Ir(III) complex as a G-quadruplex selective probe. Using uracil-DNA glycosylase (UDG) as a model enzyme, the assay achieved high sensitivity and selectivity for UDG over other tested enzymes. The utility of the assay for screening potential UDG inhibitors was also demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据