期刊
HUMAN & EXPERIMENTAL TOXICOLOGY
卷 19, 期 9, 页码 503-510出版社
NATURE PUBLISHING GROUP
DOI: 10.1191/096032700672635987
关键词
chloramphenicol; aplastic anemia; CD34 antioxidant; apoptosis
类别
Chloramphenicol (CAP), a board spectrum antibiotic widely used in many developing countries, has toxic side effects on bone marrow, the most serious of which is aplastic anemia. Recent studies suggest that effects of CAP on suppressing hematopoietic colony formation may be abrogated by antioxidants. lin addition, there is preliminary evidence that CAP induces apoptosis in hemopoietic stem cells, leading to aplastic anemia. We have been unable to demonstrate the protective effects of a variety of antioxidants on CAP-induced suppression of burst-forming unit erythroid (BFU-E) and colony-forming unit granulocyte/monocyte (CFU-GR;I). Using flow cytometry, we have, however, confirmed that CAP can induce apoptosis in purified human bone marrow CD34(+) cells. We also showed that a caspase inhibitor, Z-VAD.fmk, can ameliorate the apoptotic-inducing effects of CAP in the HL-60 cell line.
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