期刊
ORAL ONCOLOGY
卷 36, 期 5, 页码 444-449出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S1368-8375(00)00025-7
关键词
BAG-1; oral squamous cell carcinoma; T1 and T2
资金
- NCI NIH HHS [CA67329] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA067329] Funding Source: NIH RePORTER
BAG-1 is a Bcl-2-binding: protein that functions as an anti-apoptotic molecule. III this report We show a possible correlation between BAG-1 expression levels and the probability of oral squamous cell carcinoma (SCC) progression. We investigated BAG-1 expression levels in 22 patients diagnosed with early lesions (T1 and T2) of oral SCCs using immunohistochemistry and western blotting. High steady-state levels of BAG-1 were detected in 13 out of 29 cases (59%). High BAG-1 expression was observed more frequently in cases with nodal metastasis (89%) than in those without nodal metastasis (38%) (P < 0.03), suggesting that BAG-I expression levels may correlate with the pathological stage of oral SCCs. Furthermore, BAG-I expression levels correlated with the WHO grade, i.e. 45% in grade-I cases as opposed to 72% in grade-II cases (P < 0.02). These data suggest that an analysis of BAG-I expression may be useful in establishing a prognosis for patients with oral SCCs, and especially in predicting the metastatic potential of SSCs. (C) 2000 Elsevier Science Ltd. All rights reserved.
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