期刊
ORAL ONCOLOGY
卷 36, 期 2, 页码 207-213出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S1368-8375(99)00088-3
关键词
gelatin zymography; immunohistochemistry; metastasis; MMP-2; MMP-9; squamous cell carcinoma
In order to evaluate the significance of matrix metalloproteinases (MMPs) in predicting the metastatic potential of oral squamous cell carcinomas (SCCs), we compared MMP-2 and -9 expression in 19 metastasizing oral SCCs with that in 25 non-metastasizing cases by immunohistochemistry and gelatin zymography. Immunohistochemistry showed that increased MMP-2 expression was not significantly related to metastasis; increased MMP-9 expression found in oral SCCs was, however, statistically significant (oral SCCs with metastasis. 73.7%, those without metastasis, 36.0%: P < 0.05). Gelatin zymography revealed no significant difference in the activated form of MMP-2 between metastasizing and non-metastasizing oral SCCs. In metastasizing SCCs, on the other hand, increases in the activated form of MMP-9 were significant. These results suggest that oral SCCs express MMP-2 and -9, and that MMP-9 slay play a mole important role than MMP-2 in the metastasis of oral SCCs to adjacent tissue. An analysis of MMP-9 expression may be useful for predicting the metastatic potential of oral SCCs. (C) 2000 Elsevier Science Ltd. All rights reserved.
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