期刊
BIOCHIMIE
卷 82, 期 3, 页码 221-227出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S0300-9084(00)00212-1
关键词
RNA structure; ribosomal RNA; tetraloop; GNRA; UNCG
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM021499] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [T15LM007093] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM21499] Funding Source: Medline
- NLM NIH HHS [2T15LM07093] Funding Source: Medline
Terminal loops containing four nucleotides (tetraloops) are common in structural RNAs, and they frequently conform to one of three sequence motifs, GNRA, UNCG, or CUUG. Hen we compare available sequences and secondary structures for rRNAs from bacterial and we show that helices capped by phylogenetically conserved GNRA loops display a strong tendency to be of conserved length. The simplest interpretation of this correlation is that the conserved GNRA loops are involved in higher-order interactions, intramolecular or intermolecular, resulting in a selective pressure for maintaining the lengths of these helices. A small number of conserved UNCG loops were also found to be associated with conserved length helices, consistent with the possibility that this type of tetraloop also takes part in higher-order interactions. (C) 2000 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS.
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